Return Health and Glow to Damaged Skin By Renewing Collagen and Elastin and Enhancing Moisture Retention.

BIOCUTIS products with biological glycoconjugates are an alternative for treating burn scars and injured skin tissues. Its natural complex compound packed with (a) biological enhancers of intercellular and intra cellular communication and (b) enzymes that dissolve damaged skin cells and stimulate their regeneration with the amino acids they free up, supplies a complete and balanced scar removal skin care solution. The same cream made with this biological ingredient helps to lessen burn scars and other skin blemishes like those left behinf by acne lesions, rosacea, keratosis and stretch marks.

Fibroblast Growth Factor Action of BIOSKINCARE & BIOCUTIS products

Fibroblast: a type of cell that synthesizes glycosaminoglycans, reticular and elastic fibers, collagens, and glycoproteins found in the extracellular matrix. In growing individuals, fibroblasts are dividing and compounding ground elements.

Fibroblast growth factor (FGF) signaling is involved in important biological functions with differential effects in various cell types. The function of FGF is controlled by glycosaminoglycans, present both in the extracellular matrix and on the cell surface. They influence FGF signaling by interacting with both the growth factor and the Fibroblast Growth Factor receptor.

These molecules are critical in wound healing as such vital process is interactive and is conditioned by proper regulation of fibroblasts. With no regulation, excessive scarring results as a feature of weakened healing (keloid and hypertrophic scars), a serious health problem that most of the time disturbs people's quality of life for the therapy cost of such lesions is high, and often, the results are unacceptable.

The Helix Aspersa Müller Glycoconjugates Have Fibroblast Growth Factor Activity:

• Facilitates the migration of keratinocytes, thus helping to repair injuries
• Activates important fibroblast proliferation
• Enhances fibroblast operative capability, thus improving fibroplasias
• Activates production of new collagen
• Supplies hyaluronic acid (essential in all repair processes)

The glycoconjugates help achieve the correct balance between the production and degradation of substantial structural elements such as collagen and elastin

Collagenase: Enzymes that catalyze the hydrolysis of collagen and gelatin.

Gelatinase activity: A protease that starts the hydrolytic breakdown of proteins usually by splitting them into polypeptide chains. They are involved in initial tissue repair and in prolonged tissue remodeling. Several kinds of matrix metalloproteinases (collagenase and gelatinase enzymes) are selectively expressed or activated at the different periods of wound repairing and decide the presence or absence of abnormal scars: keloids or hypertrophic scars.

The matrix metalloproteinases (MMP) are a group of zinc-dependent enzymes, which degrade different parts of the extracellular skin matrix in both normal and diseased tissue. Skin matrix is a structure that maintains the skin together and consists mostly of intermeshed polymers such as collagen and elastin. The skin matrix is responsible for the skin's mechanical attributes, including suppleness, firmness, strength, and elasticity. The thinner and less regular the matrix, the more wrinkles, roughness, and sag one tends to have. Anytime skin is damaged, blemished or worn out, skin matrix is broken down by the MMP enzymes and then is recreated by the fibroblasts. Hence, MMP enzymes play a crucial role in skin physiology.

The latest approach in skin care is to maintain a healthy balance of these enzymes.

In healthy, youthful skin, the production and degradation of the matrix are in balance; flawed or excessive matrix is degraded while the deficit is restored by the ongoing production. Sadly, this intricate balance gets disrupted with age; too little of the matrix is produced and too much is degraded. MMP levels increase excessively with age. Research demonstrates that reversal of MMP levels to normal youthful levels in aged patients is an efficient method to remove the flawed matrix and preserve the healthy one. For this purpose, the use of MMP inhibitors in the form of drugs, cosmetic formulations, and lifestyle changes is the latest cosmetic find.

Function of fibroblasts

The main function of fibroblasts is to maintain the structural integrity of connective tissue by continuously producing precursors of the extracellular matrix. Fibroblasts produce the precursors of all the elements of the extracellular matrix, primarily the ground complex and a variety of fibers. The composition of the extracellular matrix determines the physical characteristics of connective tissues. Proteoglycans (proteins united to glycosaminoglycans or glycoproteins) join multiple elements of the extracellular matrix by serving as vital regulators of cellular behavior. Tissue destruction stimulates fibrocytes and induces migration and readily proliferation of fibroblasts in multiple stages of tissue repair including wound contraction. Fibroblasts can give rise to other cells, such as bone cells, fat cells, and smooth muscle cells. All these are cells of mesodermal origin, which means a layer from which the organs and tissues of the body develop through further differentiation.

Growth factors are polypeptides (proteins) that join to receptors on the cell surface, with the main result of initiating cellular proliferation and/or differentiation. Many growth factors are very versatile, stimulating cellular division in several different cell types; while others are specific to a particular cell-type. There are at least 21 different members of the FGF family of growth factors.

Fibroblast growth factors work specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, some kinds of Fibroblast Growth Factor have been shown to be more than growth factors: they can protect epithelial cells from damaging effects made, for example, by radiation and oxidative stress. Hence, they are currently in clinical tests for the therapy of oral mucositis, a severe side-effect of cancer treatments characterized by painful inflammation and wounding of the oral epithelium. Reference: “Fibroblast growth factors in epithelial repair and cytoprotection”. Susanne Braun, Ulrich auf dem Keller, Heike Steiling and Sabine Werner Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH-8093 Zurich, Switzerland. April 2004.

Choose a product according to your skin condition

Intense treatment serum to thorougly revitalize your skin. Apply 3 to 4 times a year for periods of 8 weeks once a day before bedtime.	For routine maintenance of normal and oily skin. Keeps skin deeply moisturized & looking younger & radiant.	For sensitive dry skin prone to allergies, eczema, dermatitis and rosacea.	To moisturize skin & get rid of dark pigmentation, age spots and rough sun damaged skin.
30 ml = $99.98	$69.98 Get two & save $24	$69.99	$79

All products contain enough for one month when applied twice a day. Since we recommend applying the BIOSKINREVITALIZER before bedtime and any one of the other products in the morning, by using both products you will treat yourself to yield outstanding results in less than 60 days.

Best value - 60 day supply - limited time offers:

$ 169.96 $135.95 You save $34.01	$ 169.96 $135.95 You save $34.01	$ 179.96 $145.95 You save $34.01

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